abstract：Objective:The N-methyl-D-aspartate subtype glutamate receptor antagonist ketamine has rapid antidepressant and antisuicidal effects in treating treatment-resistant bipolar depression (TRBD). The neurocognitive effects of repeated ketamine infusions in TRBD are not known. Methods:Six intravenous infusions of ketamine (...

journal_title：PeerJ

authors： Zheng W,Zhou YL,Wang CY,Lan XF,Zhang B,Yang MZ,Nie S,Ning YP

更新日期：2020-11-03 00:00:00

abstract：Background:In the absence of highly effective antiviral therapies against SARS-CoV-2, it is crucial to counter the known pathophysiological causes of severe COVID-19. Evaluating the efficacy existing drugs may expedite the development of such therapeutics. Severe COVID-19 is largely the result of a dysregulated immune ...

journal_title：PeerJ

authors： Kaye AG,Siegel R

更新日期：2020-11-02 00:00:00

abstract：:Due to varietal differences, diminutive size, and similar morphological characters, it is difficult to classify and identify Liriomyza spp., a genus comprised of economically-important, highly-polyphagous insect pests. In this study, we reconfirmed the morphological characteristics of three closely-related invasive le...

journal_title：PeerJ

authors： Chang YW,Chen JY,Zheng SZ,Gao Y,Chen Y,Deng Y,Du YZ

更新日期：2020-10-30 00:00:00

abstract：Background:Wearable activity trackers are regarded as a new opportunity to deliver health promotion interventions. Indeed, while the prediction of active behaviors is currently primarily relying on the processing of accelerometer sensor data, the emergence of smart clothes with multi-sensing capacities is offering new ...

journal_title：PeerJ

authors： Ren D,Aubert-Kato N,Anzai E,Ohta Y,Tripette J

更新日期：2020-10-28 00:00:00

abstract：Background:High heel shoes (HHS) can affect human postural control because elevated heel height (HH) may result in plantar flexed foot and limit ankle joint range of motion during walking. Effects of HH and HHS wearing experience on postural stability during self-initiated and externally triggered perturbations are les...

journal_title：PeerJ

authors： Chen Y,Li JX,Wang L

更新日期：2020-10-28 00:00:00

abstract：Background:Oil spills can cause severe damage within a marine ecosystem. Following a spill, the soluble fraction of polycyclic aromatic hydrocarbons is rapidly released into the water column. These remain dissolved in seawater over an extended period of time, even should the insoluble fraction be removed. The vertical ...

journal_title：PeerJ

authors： Kryzevicius Z,Mickuviene K,Bucas M,Vilkiene M,Zukauskaite A

更新日期：2020-10-27 00:00:00

abstract：Purpose:Recent studies have determined that long non-coding RNAs (lncRNAs) are potential prognostic biomarkers for non-small cell lung cancers (NSCLCs). The purpose of this study was to analyze the function and associated pathways of zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) in NSCLC cells. Methods:W...

journal_title：PeerJ

authors： Wang X,Tang J,Zhao J,Lou B,Li L

更新日期：2020-10-26 00:00:00

abstract：Background:Morphological differentiation between populations resulting from local adaptations to environmental conditions is likely to be more pronounced in populations with increasing genetic isolation. In a previous study a positive clinal variation in body size was observed in isolated Roesel's bush-cricket, Metriop...

journal_title：PeerJ

authors： Kaňuch P,Kiehl B,Cassel-Lundhagen A,Laugen AT,Low M,Berggren Å

更新日期：2020-10-22 00:00:00

abstract：Background:Immunoglobulin superfamily member 10 (IGSF10) is a member of the immunoglobulin superfamily that is expressed at high levels in both the gallbladder and ovary. Currently, the role and possible mechanism of IGSF10 in breast cancer remain unclear. Method:By applying real-time quantitative polymerase chain rea...

journal_title：PeerJ

authors： Wang M,Dai M,Wu YS,Yi Z,Li Y,Ren G

更新日期：2020-10-21 00:00:00

abstract：:Koalas (Phascolarctos cinereus) are highly specialized herbivorous marsupials that feed almost exclusively on Eucalyptus leaves, which are known to contain varying concentrations of many different toxic chemical compounds. The literature suggests that Lonepinella koalarum, a bacterium in the Pasteurellaceae family, ca...

journal_title：PeerJ

authors： Dahlhausen KE,Jospin G,Coil DA,Eisen JA,Wilkins LGE

更新日期：2020-10-20 00:00:00

abstract：:Ethylene response factors (ERFs) are plant-specific transcription factors (TFs) that play important roles in plant growth and stress defense and have received a great amount of attention in recent years. In this study, seven ERF genes related to abiotic stress tolerance and response were identified in plants of the Po...

journal_title：PeerJ

authors： Huang J,Wang S,Wang X,Fan Y,Han Y

更新日期：2020-10-20 00:00:00

abstract：:The expansion of the wind energy industry has had benefits in terms of increased renewable energy production but has also led to increased mortality of migratory bats due to interactions with wind turbines. A key question that could guide bat-related management activities is identifying the geographic origin of bats k...

journal_title：PeerJ

authors： Wieringa JG,Nagel J,Nelson DM,Carstens BC,Gibbs HL

更新日期：2020-10-19 00:00:00

abstract：:Maternal thyroid hormones (THs) are known to be crucial in embryonic development in humans, but their influence on other, especially wild, animals remains poorly understood. So far, the studies that experimentally investigated the consequences of maternal THs focused on short-term effects, while early organisational e...

journal_title：PeerJ

authors： Sarraude T,Hsu BY,Groothuis T,Ruuskanen S

更新日期：2020-10-16 00:00:00

abstract：Background:"Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. adiponectin) is high or low relative to its distribution. We have previously shown that the heritability (h2 ) of adiposity, lipoproteins, postprandial lipemia, pulmonary function, and ...

journal_title：PeerJ

authors： Williams PT

更新日期：2020-10-14 00:00:00

abstract：Background and Purpose:Several studies have proposed that the advanced lung cancer inflammation index (ALI), a new inflammation-related index, can be used for the prognosis assessment of various malignancies. However, few studies have reported its prognostic value in colorectal cancer (CRC). Therefore, this study explo...

journal_title：PeerJ

authors： Xie H,Huang S,Yuan G,Kuang J,Yan L,Wei L,Tang S,Gan J

更新日期：2020-10-08 00:00:00

abstract：:Taphonomic deformation, the distortion of fossils as a result of geological processes, poses problems for the use of geometric morphometrics in addressing paleobiological questions. Signal from biological variation, such as ontogenetic trends and sexual dimorphism, may be lost if variation from deformation is too high...

journal_title：PeerJ

authors： Kammerer CF,Deutsch M,Lungmus JK,Angielczyk KD

更新日期：2020-10-07 00:00:00

abstract：:Herein, we identified the tomato SlMYB102 gene as a MYB family transcription factor of the R2R3-MYB subfamily. We additionally determined that the SlMYB102 promoter region contains photoresponsive, abiotic stress-responsive, and hormone-responsive regulatory elements, and we detected higher SlMYB102 expression in the ...

journal_title：PeerJ

authors： Wang M,Hao J,Chen X,Zhang X

更新日期：2020-10-07 00:00:00

abstract：Background:The fecal microbiota from obese individuals can induce obesity in animal models. In addition, studies in humans, animal models and dogs have revealed that the fecal microbiota of subjects with obesity is different from that of lean subjects and changes after weight loss. However, the impact of weight loss on...

journal_title：PeerJ

authors： Bermudez Sanchez S,Pilla R,Sarawichitr B,Gramenzi A,Marsilio F,Steiner JM,Lidbury JA,Woods GRT,German AJ,Suchodolski JS

更新日期：2020-10-05 00:00:00

abstract：:It is deemed important to understand cetacean occurrence and distribution to comprehend their ecological roles. The geographical occurrence of species' niche can be used to better describe their potential distribution. The niche can be defined using environmental variables. Those variables are considered static and no...

journal_title：PeerJ

authors： Figueiredo GCE,do Amaral KB,Santos MCO

更新日期：2020-10-05 00:00:00

abstract：:At the turn of February and March 2020, COVID-19 pandemic reached Europe. Many countries, including Poland imposed lockdown as a method of securing social distance between potentially infected. Stay-at-home orders and movement control within public space not only affected the touristm industry, but also the everyday l...

journal_title：PeerJ

authors： Szczepanek R

更新日期：2020-10-05 00:00:00

abstract：:Local ancestry estimation infers the regional ancestral origin of chromosomal segments in admixed populations using reference populations and a variety of statistical models. Integrating local ancestry into complex trait genetics has the potential to increase detection of genetic associations and improve genetic predi...

journal_title：PeerJ

authors： Schubert R,Andaleon A,Wheeler HE

更新日期：2020-10-02 00:00:00

abstract：:As coral reefs continue to decline globally, coral restoration practitioners have explored various approaches to return coral cover and diversity to decimated reefs. While branching coral species have long been the focus of restoration efforts, the recent development of the microfragmentation coral propagation techniq...

journal_title：PeerJ

authors： Koval G,Rivas N,D'Alessandro M,Hesley D,Santos R,Lirman D

更新日期：2020-10-02 00:00:00

abstract：Background:Human population growth has led to biodiversity declines in tropical cities. While habitat loss and fragmentation have been the main drivers of urban biodiversity loss, man-made interventions to reduce health risks have also emerged as an unintentional threat. For instance, insecticide fogging to control mos...

journal_title：PeerJ

authors： Lee NSM,Clements GR,Ting ASY,Wong ZH,Yek SH

更新日期：2020-10-01 00:00:00

abstract：Background:The functional significance of ADAMs family members in the immune infiltration of pancreatic adenocarcinoma (PAAD) awaits elucidation. Methods:ADAMs family members with significant expression were identified among differentially expressed genes of PAAD based on The Cancer Genome Atlas (TCGA) database follow...

journal_title：PeerJ

authors： Qi B,Liu H,Dong Y,Shi X,Zhou Q,Zeng F,Bao N,Li Q,Yuan Y,Yao L,Xia S

更新日期：2020-09-30 00:00:00

abstract：:Zoigê Plateau, China's largest plateau marsh wetland, has experienced large-scale degradation of the marsh wetland and evolution of the wetland landscape pattern over the past 40 years due to climate warming and human activities. How exactly do the wetland landscape pattern characteristics change? How do climatic chan...

journal_title：PeerJ

authors： Dong L,Yang W,Zhang K,Zhen S,Cheng X,Wu L

更新日期：2020-09-29 00:00:00

abstract：Background:Due to intensive sluice construction and other human disturbances, lakeshore vegetation has been destroyed and ecosystems greatly changed. Rhizospheric microbiota constitute a key part of a functioning rhizosphere ecosystem. Maintaining rhizosphere microbial diversity is a central, critical issue for sustain...

journal_title：PeerJ

authors： Zhang X,Wang H,Li Z,Xie J,Ni J

更新日期：2020-09-29 00:00:00

abstract：Background:The circadian clock not only participates in regulating various stages of plant growth, development and metabolism, but confers plant environmental adaptability to stress such as drought. Pseudo-Response Regulators (PRRs) are important component of the central oscillator (the core of circadian clock) and pla...

journal_title：PeerJ

authors： Wang J,Du Z,Huo X,Zhou J,Chen Y,Zhang J,Pan A,Wang X,Wang F,Zhang J

更新日期：2020-09-25 00:00:00

abstract：Background:Pandi's mushroom-tongue salamander (Bolitoglossa pandi) is one of the threatened amphibians in South America, as well as a flagship species for the Colombian conservation agenda. This species is endemic to the Andean cloud forests of the western slope of the Cordillera Oriental of Colombia, occurring only in...

journal_title：PeerJ

authors： Angarita-Sierra T,Bonilla-Gómez MA,Sánchez DA,Acosta-Galvis AR,Medina-Ovalle H,Solano-Moreno A,Ulloa-Rengifo S,Guevara-Guevara D,Torres-Ramirez JJ,Curaca-Fierro S,Cabrera-Amaya DM,Infante-Betancour JA,Londoño-Montaño LF,Albarán

更新日期：2020-09-24 00:00:00

abstract：Background:The highest rate of cancer-related deaths worldwide is from lung adenocarcinoma (LUAD) annually. Metabolism was associated with tumorigenesis and cancer development. Metabolic-related genes may be important biomarkers and metabolic therapeutic targets for LUAD. Materials and Methods:In this study, the glean...

journal_title：PeerJ

authors： Zhao Z,He B,Cai Q,Zhang P,Peng X,Zhang Y,Xie H,Wang X

更新日期：2020-09-24 00:00:00

abstract：:Limestone karsts of Southeast Asia can harbor high levels of endemism, but are highly fragmented, increasingly threatened, and their biodiversity is often poorly studied. This is true of the Padawan Limestone Area of Sarawak, Malaysia, home to the endemic Artocarpus annulatus, the closest known wild relative of two im...

journal_title：PeerJ

authors： Dickinson L,Noble H,Gardner E,Puad ASA,Zakaria WNFW,Zerega NJC

更新日期：2020-09-21 00:00:00

abstract：:The combination of different approaches has successfully delimited new species within many Neotropical species complexes traditionally classified as a single nominal organism. Recent studies have shown that the Amazonian endemic genus Amazophrynella, currently composed of 12 small-sized species, could harbor several a...

journal_title：PeerJ

authors： Mângia S,Koroiva R,Santana DJ

更新日期：2020-09-18 00:00:00

abstract：:Body condition is an important determinant of health, and its evaluation has practical applications for the conservation and management of mammals. We developed a noninvasive method that uses photographs to assess the body condition of free-ranging brown bears (Ursus arctos) in the Shiretoko Peninsula, Hokkaido, Japan...

journal_title：PeerJ

authors： Shirane Y,Mori F,Yamanaka M,Nakanishi M,Ishinazaka T,Mano T,Jimbo M,Sashika M,Tsubota T,Shimozuru M

更新日期：2020-09-18 00:00:00

abstract：Background:Despite clinical trials with antioxidant supplementation, few studies have been conducted to evaluate the nutritional status of antioxidant vitamins and minerals, and none have reported on the status of these serum antioxidants associated with the dietary intake of antioxidants by non-alcoholic fatty liver d...

journal_title：PeerJ

authors： Coelho JM,Cansanção K,Perez RM,Leite NC,Padilha P,Ramalho A,Peres W

更新日期：2020-09-17 00:00:00

abstract：:The cryptic species that make up the Euwallacea fornicatus species complex can be readily distinguished via their DNA sequences. Until recently, it was believed that the Hawaiian Islands had been invaded by only one of these cryptic species, E. perbrevis (tea shot hole borer; TSHB). However, following the 2016 deposit...

journal_title：PeerJ

authors： Rugman-Jones PF,Au M,Ebrahimi V,Eskalen A,Gillett CPDT,Honsberger D,Husein D,Wright MG,Yousuf F,Stouthamer R

更新日期：2020-09-17 00:00:00

abstract：Background:Trace elements are essential for the growth and survival of plants, and their concentrations and distributions in plants are effective reflections of ecological adaptation strategies. However, this aspect has seldom been addressed. Method:Changes in the leaf and branch trace elements of Pinus massoniana Lam...

journal_title：PeerJ

authors： Lin T,Zheng X,Zheng H

更新日期：2020-09-16 00:00:00

abstract：Background/Aims:Medical and behavioral needs are relevant in organizing and providing support strategies that improve the quality of life for children, along with their families. The present study aims to examine the impact of medical and behavioral needs on the need for support of children with disabilities. Methods:...

journal_title：PeerJ

authors： Arias VB,Aguayo V,Verdugo MA,Amor AM

更新日期：2020-09-15 00:00:00

abstract：Objective:To explore the blood pressure response to different ablation points of renal denervation (RDN) in patients with resistant hypertension. Methods:A total of 42 cases with resistant hypertension treated by RDN in our center from 2013 to 2015 were retrospectively analyzed. The patients were divided into two grou...

journal_title：PeerJ

authors： Zhang H,Li LY,Xiao RX,Zhang TC,Liu ZJ,Gao JQ

更新日期：2020-09-15 00:00:00

abstract：Background:Endometriosis (EMs) is a non-malignant gynecological disease, whose pathogenesis remains to be clarified. Recent studies have found that hypoxia induces epithelial-mesenchymal transition (EMT) as well as epigenetic modification in EMs. However, the relationship between EMT and demethylation modification unde...

journal_title：PeerJ

authors： Wu J,Li X,Huang H,Xia X,Zhang M,Fang X

更新日期：2020-09-15 00:00:00

abstract：:Alcohol drinking may be associated with an increased risk of various metabolic diseases. Rat lines selectively bred for alcohol preference and alcohol avoidance constitute an interesting model to study inherited factors related to alcohol drinking and metabolic disorders. The aim of the present study was to compare th...

journal_title：PeerJ

authors： Mierzejewski P,Zakrzewska A,Kuczyńska J,Wyszogrodzka E,Dominiak M

更新日期：2020-09-11 00:00:00

abstract：:Despite being geographically central to the Atlantic Americas Flyway for migratory birds, the Caribbean is often overlooked or underappreciated when addressing the conservation of North American shorebirds. To our knowledge, this is the first Caribbean-wide assessment of shorebird use in the region. We analyzed 211,01...

journal_title：PeerJ

authors： Cañizares JR,Reed JM

更新日期：2020-09-08 00:00:00